Clinical Trials

Clinical trials are research studies in which new treatments are tested against current standard treatments. They involve patients taking new drugs or undergoing new treatments to see whether these are effective in combating disease.

There are numerous breast cancer clinical trials currently underway throughout New Zealand and the rest of the world. These aim to identify new and more effective ways of treating breast cancer or ways of preventing it from occurring.

On this page you can find out more about how clinical trials work and the clinical trials that are currently underway in New Zealand. To find out more about the latest international research, check out our research news.

  • How does a clinical trial work?
    Research nurse Jenni Scarlett tells us more about clinical trials,the different types of trials, reasons for participating and trial protocols.
  • Why participate in a clinical trial?
    Breast cancer survivor Raewyn Calvert has been involved in a cinical trial and talks about reasons to participate in breast cancer research.
  • The SORBET trial  (closed and now in follow-up)
    This clinical trial looks at the possibility of treating women with Triple Negative Breast Cancer with Tamoxifen.
  • The Marianne Trial (closed and in follow-up)
    An international trial which will involve up to 1092 patients with HER2-positive breast cancer.  This study aims to evaluate the efficacy and safety of using a new drug known T-DM1. This trial is only open to women in Waikato and Auckland.  You can find out more about research into TDM-1 here.
  • The SNAC-2 Trial
    This trial compares two operations for detecting cancer cells in the lymph nodes of women with early breast cancer - sentinal node biopsy versus auxillary clearance.  It is open to wwomen in the North Shore, Waikato, Christchurch, Palmerston North and Tauranga.
  • The Trog Trial (closed and in follow-up)
    This trial is for women who have ductal carcinoma in situ (DCIS) of the breast and aims to see whether improvements can be made to radiation treatment by giving women an extra treatment dose.  It is available to women in Waikato, Christchurch and Auckland.
  • The STARS Trial
    This clinical trial compares the order of treatments for women who have oestrogen and/or progesterone receptor positive breast cancer and need both radiation treatment and hormone medication (anastrozole) to control the breast cancer following surgery. In New Zealand the trial is open in Auckland, Palmerston North and Christchurch.
  • The Eliminate Trial

    The Eliminate trial will investigate whether combining two breast cancer treatments before surgery is more effective than one treatment alone for women with large and complex ER+ breast cancer.

  • Will an adapted Mediterranean diet (BC-MED) improve health in breast cancer survivors? (closed and in follow-up)
    This trial will investigate whether an adapted Mediterranean diet improves health outcomes for women who have been treated for early stage breast cancer. The study investigators aim to test whether a Mediterranean diet helps those who’ve been treated for breast cancer to lose weight, reduce the symptoms of metabolic syndrome and lower inflammation levels in order to improve overall health.

  • Immunotherapy Trial

The trial will investigate using the drug Pembrolizumab (Keytruda) as Monotherapy (treatment by a single drug) in patients with metastatic Triple Negative Breast Cancer.

POSNOC - POsitive Sentinel NOde: adjuvant therapy alone versus adjuvant therapy plus Clearance or axillary radiotherapy. A randomised controlled trial of axillary treatment in women with early stage breast cancer who have metastases in one or two sentinel nodes.